S-Adenosyl L-Methionine (SAMe) + Methylcobalamin + L-5 Methyltetrahydrofolate Calcium Tablets

Project Image
Thumb Image

Therapeutic Indication

Diabetic neuropathy & peripheral neuropathy
Liver health & detoxification
Vitamin B-complex deficiency
Depression & mood regulation
Cardiovascular health & homocysteine reduction
+91 85919 78885

Zinc Sulphate

Tablet

This combination therapy is used to manage erectile dysfunction and premature ejaculation. Tadalafil improves penile blood flow by inhibiting PDE5, while Dapoxetine, a short-acting SSRI, delays ejaculation by increasing serotonin activity.

Speciality Neurology | Hepatology | Cardiology | General Medicine
Tags Neuro Support | Antioxidant | Liver Health | Mood Balance
Strength
  • SAMe 400 mg
  • Methylcobalamin 500 mcg
  • L-5 Methyltetrahydrofolate Calcium 500 mcg
Packing Size
  • 10 Tablets

Check all Women Range

Click to know More

Mechanism

  • SAMe: Universal methyl donor, supports liver detoxification and neurotransmitter synthesis.
  • Methylcobalamin: Active B12, essential for DNA synthesis and nerve regeneration.
  • L-5 MTHF Calcium: Active folate, reduces homocysteine, supports neurotransmitter production.

Pharmacokinetics

  • Absorption: SAMe is absorbed in the small intestine; bioavailability improves with enteric-coated formulations. Methylcobalamin and L-5 MTHF Calcium are rapidly absorbed, bypassing conversion steps required by inactive forms.
  • Distribution: SAMe is widely distributed in hepatic tissue and crosses the blood-brain barrier. Methylcobalamin circulates bound to transcobalamin II, reaching nervous tissue. L-5 MTHF Calcium distributes to plasma and cerebrospinal fluid, supporting methylation pathways.
  • Metabolism: SAMe undergoes hepatic metabolism via transmethylation and transsulfuration pathways. Methylcobalamin acts as a coenzyme in methionine synthase reactions. L-5 MTHF Calcium directly participates in homocysteine remethylation without requiring enzymatic conversion.
  • Elimination: SAMe metabolites are excreted via urine and bile. Methylcobalamin is primarily eliminated renally. Folate derivatives are excreted in urine, with some biliary recycling.

Side Effects

  • Mild gastrointestinal upset
  • Headache, irritability (rare)
  • Allergic reactions (rash, itching)

Contraindication

  • Hypersensitivity to any component
  • Severe hepatic impairment without medical supervision

Interaction

  • Nitrates (risk of severe hypotension)
  • Other SSRIs or MAO inhibitors (risk of serotonin syndrome)

Warning and Precautions

  • Use cautiously in patients with cardiovascular disease
  • Avoid alcohol (may worsen side effects)
  • Not recommended for patients under 18 years

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.